Sunday, January 31, 2010

Myco-Z

MYCO-Z®
Ointment
(Nystatin and Zinc Oxide)

COMPOSITION
Each gram Myco-Z® ointment contains 100,000 units of nystatin and 200 mg of zinc oxide in a perfumed Plastibase®, an emollient and protective vehicle.

PHARMACOLOGY
Nystatin is an antifungal antibiotic which is both fungistatic and fungicidal in vitro against a wide variety of yeast and yeast like fungi. It probably acts by binding to sterols in the cell membrane of the fungus with a resultant change in membrane permeability allowing leakage of intracellular components.
Nystatin is a polyene antibiotic of undetermined structural formula that is obtained from Streptomyces noursei, and is the first well tolerated antifungal antibiotic of dependable efficacy for the treatment of cutaneous, oral and intestinal infections caused by Candida (Monilia) albicans and other Candida species. It exhibits no appreciable activity against bacteria.

Nystatin provides therapy for all localized forms of candidiasis.
Symptomatic relief is rapid, often occurring within 24 to 72 hours after the initiation of treatment.
Cure is effected both clinically and mycologically in most cases of localized candidiasis.

Zinc oxide is applied externally as a mild astringent for the skin, as a soothing and protective application in eczema and as a protective to slight excoriations.

INDICATIONS
Myco-Z® ointment is indicated in the treatment of cutaneous mycotic infections caused by Candida (Monilia) albicans. If the organism is the primary cause of infection, such dermatologic conditions as intertrigo(submammary, inguinal and perineal), paronychia, interdigital mycosis, 'diaper rash' and other cutaneous lesions can be expected to respond.

CONTRAINDICATIONS
MYCO-Z® ointment is contraindicated in patients with known hypersensitivity to these components.

ADVERSE REACTIONS
Nystatin is virtually nontoxic and nonsensitizing. Myco-Z® ointment is well tolerated by all age groups including debilitated infants, even on prolonged administration. If irritation on topical application should occur, discontinue medication.

OVERDOSAGE
Since absorption of nystatin from the gastro-intestinal tract is negligible, accidental ingestion causes no systemic toxicity.

DOSAGE AND ADMINISTRATION
The ointment should be applied liberally to the affected areas two to four times daily, until healing is complete.

HOW SUPPLIED
Myco-Z® ointment is supplied in tubes of 10 grams.

STORAGE
Store below 30°C. Avoid freezing

HARUS DENGAN RESEP DOKTER
Reg. No.: DKL 9024402730 A1

Manufactured by
PT Bristol-Myers Squibb IndonesiaTbk
Bogor-Indonesia
Under authority of
Bristol-Myers Squibb Co.,
Princeton, New Jersey, U.S.A.

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