Impugan

Impugan®

Composition
Each film coated tablet contains:
Furosemide 40 mg

Description
Furosemide exerts a diuresis (sodium) effect correlated to the dosages. The diuretic effects of furosemide are evident within 30 minutes to 1 hour after oral administration and the maximal effect achieved within 1 to 2 hours and last for about 4 to 6 hours.
Unlike thiazide, furosemide still shows its effects in renal insufficiency.

Indications

• Edema associated with congestive heart failure, cirrhosis of the liver, and renal disease, including the nephrotic syndrome.
• For the treatment of hypertension alone or in combination with other antihypertensive agents. 

Contra indications

• Anuria
• Hypersensitivy to furosemide or sulphonamide.

Posology
Edema
Adults:
The initial dose is 20-80 mg in a single dose. If needed, the same dose can be repeated after 6 to 8 hours. The dose may be increased up to 20-40 mg, every 6-8 hours, until the satisfactory response is obtained, then the dose can be given once or twice daily. The dose may be increased to maximum 600 mg / day in patients with severe edema.
Pediatric patients
The initial dose is 1-2 mg / kg body weight, as a single dose. If the diuretic response is not satisfactory, dosage may be increased by 1-2 mg/kg every 6-8 hours until the desired response is obtained. The maximal dose is 6 mg/kg body weight. For maintenance therapy, the dose should be adjusted to the minimum effective level.

Hypertension:
Adults: 40 mg twice a day. Dosage should then be adjusted according to the response.

Side Effects

• Gastrointestinal system reactions: Nausea, diarrhea, pancreatitis, jaundice, anorexia, oral and gastric irritation, vomiting, cramping and constipation.
• Systemic Hypersensitivity reactions: Systemic vasculitis, intersititial nephritis, necrotizing angiitis
• Central Nervous System, reactions: Tinnitus and hearing loss, paraesthesias, vertigo, dizziness, and headache.
• Hematologic reactions: Thrombocytopenia, hemolytic anemia, leukopenia and anemia.
• Dermatologic reactions: Exfoliative dermatitis, erythema multiforme, purpura, photosensitivity, rash and urticaria.
• Cardiovascular reactions: Orthostatic hypotension.
• Other reactions: Hyperglycemia, glycosuria, hyperuricemia.

Warnings and Precautions

• Furosemide should be used with caution in patient with electrolyte deficiency.
• Furosemide should be used during pregnancy and breast feeding, only if clearly needed or in the short-term therapy
• In overdosage could cause dehydration, electrolyte deficiency, especially in elderly patients.
• During long-term treatment with these high dose forms of furosemide therapy, careful laboratory control is essential.
• If increasing azotemia and oliguria occur during treatment of severe progressive renal disease, furosemide should be discontinued.

Drug Interactions

• Furosemide may increase the ototoxic potential of aminoglycoside antibiotic, especially in the presence of impaired renal function.
• With probenecid may inhibits the tubule secretion of furosemide
• May increase risk ofsalicylate and lithium toxicity

Overdosage
The principal signs of symptoms of overdosage with Furosemide are: dehydration, blood volume reduction, hypotension, electrolyte imbalance, hypokalemia and hypochloremic alkalosis.
Treatment of overdosage is supportive and consist of replacement of excessive fluid and electrolyte losses.

Packaging
Impugan film coated tablet are available in box of 100 tablets (10 strips 010 tablets)
Reg. No.: DKL7405505217A1

Storage
Store in a cool (15ºC - 25ºC), dry place and away from light.

HARUS DENGAN RESEP DOKTER

This leaflet was last revised in August 2006

Manufactured by
PT Actavis Indonesia, Jakarta
(Group of Actavis, Iceland)

Share this :