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Kanamycin Capsules

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KANAMYCIN CAPSULES "MEIJI"

PROPERTIES
Kanamycin is an aminoglycoside antibiotic produced by Streptomyces kanamyceticus. The aminoglycosides bind to the bacterial 30 S ribosomal sub-unit in the inhibition of bacterial cell protein synthesis.
The bactericidal effect Kanamycin is to the Gram-negative and Gram-positive bacteria as well.
Kanamycin capsules administered orally and hardly absorbed from the digestive tract. Therefore Kanamycin capsules Meiji are only administered to treat for bowel sterilization and adjunct in the treatment of hepatic coma.

COMPOSITION
Each capsule of KANAMYCIN CAPSULES MEIJI contains 250 mg (Base) of Kanamycin monosulfate.

INDICATIONS
Kanamycin capsules taken orally is hardly absorbed from the alimentary canal, so, not for systemic use; it is only for sterilization of gastrointestinal tract preoperatively and adjunct in the treatment of hepatic coma.

ADMINISTRATION AND DOSAGE 
For bowel sterilization:
Adult:
1 g every hour for 4 hours, and then 1 g every 6 hours for 36 - 72 hours.

Children and babies:
150 - 250 mg / kg / day in divide dosage every hour for 6 hours.

For adjunct in the treatment of hepatic coma:

Adult:
8 - 12 g a day in divide dosage

PRECAUTIONS
Administered carefully to the following patients:
  1. Patients with renal impairment, hearing impairment or intestinal ulcer.
  2. Orally poorly nourished or parenterally nourished patients, elderly patients and patients in poor general health. (Sufficient observation should be performed because vitamin K deficiency may develop).
  3. Renal function should be checked before and after therapy.
  4. Even though this drug is hardly absorbed, but if the renal impairment the side effect may occur.

SIDE EFFECTS
Administration of Kanamycin could induced damage of the VIII cranial nerve. If tinnitus, dizziness or vertigo occurs, administration should be discontinued.
In some others patients nephrotoxic, headache, numbness, nausea, vomiting, diarrhoea, and loose stool may occur.
A malabsorption syndromes after prolonged oral preparation with fatty faeces, decreases carotene, and failure of xylose absorption.
Super infection with fungi occurs during therapy particularly if the treatment is prolonged.
Acute muscular paralysis and apnea can occur following treatment with aminoglycoside antibiotics.

CONTRA INDICATIONS
Administration of the drug should be avoided to the intestinal obstructive and hypersensitivity to aminoglycoside such as : Fradiomycin, Streptomycin, Gentamycin, etc.
Effect upon the foetus must be considered if aminoglycoside is administered during pregnancy.
Kanamycin is not effective for the microorganism which not sensitive.
This drug is not indicated in long term therapy (e.g. Tuberculosis) because of the toxic hazard associated with extended administration.

STORAGE AND DURATION
Kanamycin Capsules Meiji may be stored in a cool dry place and should be used before expiration date stated on the label.

HOW SUPPLlED
KANAMYCIN CAPSULES 250 mg (Base) :
10 blisters @ 10 capsules / box. Reg. No. DKL 9115301101A1

This drug should be administered by or under the supervision of a physician.

HARUS DENGAN RESEP DOKTER

PT. MEIJI INDONESIAN PHARMACEUTICAL INDUSTRIES
Bangil - Pasuruan, Jawa Timur - Indonesia

Licensed by
MEIJI SEIKA KAISHA, LTD.
Tokyo, Japan.

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